128892-34-2

Upstream product

• 33099-08-0 N-benzyloxycarbonyl-N-methyl-L-leucine 
• 3339-44-4 methyl N-methyl-L-valinate hydrochloride 
• 53363-91-0 2-(N-benzyloxycarbonyl-N-methylamino)-3-methylbutyric acid methyl ester 
• 33099-10-4 Methyl N-methyl-L-valinate hydrobromide 

Relevant academic research and scientific papers

Convergent synthesis of dolastatin 15 by solid phase coupling of an N- methylamino acid

Convergent synthesis of dolastatin 15 (1), a cytostatic depsipeptide isolated from the Indian Ocean sea hare, has been described. For construction of the backbone, a single-step condensation of peptide fragment 2 and pyrrolidone fragment 3 was successfull

BroP: A new reagent for coupling N-methylated amino acids

BroP (bromo tris(dimethylamino) phosphonium hexafluorophosphate) is a particularly suitable reagent for coupling N-methylated amino acids. It is stable and gives very high yields in short reaction times. Dipeptides are obtained without appreciable epimeri