1288943-45-2Relevant academic research and scientific papers
Synthesis of tetraethyl (2-benzyl-3-oxoisoindolyl-1,1-diyl)-bisphosphonate and its properties
Zemlyanoi,Kolodyazhnyi
, p. 1105 - 1110 (2011)
The reaction of o-phthalyl chloride with sodium diethylphosphite affords a cyclic bisphosphonate, 3,3-bis(diethylphosphono)-1(3H)-isobenzofuranone. The reaction of 1(3H)-isobenzofuranone with potassium carbonate proceeds through the ring opening and elimination of one phosphonate group to give acyclic a-ketophosphonate. At the same time, the reaction of bisphosphonate with the concentrated hydrochloric acid does not lead to the ring opening but gives bisphosphonic acid in a good yield. 3,3-Bis(diethylphosphono)- 1(3H)-isobenzofuranone reacts with benzylamine in the presence of triethylamine with the replacement of endocyclic oxygen atom by benzylamino group, which leads to the formation of the corresponding bisphosphonate phthalimide, the first representative of a new type of bisphosphonates and phosphorus heterocycles. Pleiades Publishing, Ltd., 2011.
Synthesis of 3,3-bis(diethylphosphono)-1-(3H)-isobenzofuranone and its chemical properties
Zemlianoy, Viacheslav N.,Chernega, Alexander,Gutov, Alexey V.,Kolodiazhna, Anastasy O.,Kolodiazhnyi, Oleg I.
, p. 481 - 488 (2011/05/15)
The reaction of o-phthaloyl chloride with sodium diethylphosphite leads to the formation of cyclic bisphosphonate-a 3,3-bis(diethylphosphono)-1(3H)- isobenzofuranone. The hydrolysis of 1-(3H)-isobenzofuranone with aqueous potash results in the acyclic α-k
3,3-Bis(Diethylphosphono)-1(3H)- isobenzofuranone and its properties
Zemlianoy,Kolodiazhna,Gutov,Chernega,Kukhar,Kolodiazhnyi
scheme or table, p. 772 - 774 (2011/07/08)
The reaction of o-phthaloyl chloride with sodium diethylphosphite led to the formation of new 3,3-bis(diethylphosphono)-1-(3H)-isobenzofurane 1. The reaction of bisphosphonate with alkylamine occurs with replacement of an ester oxygen by an imine group to
