1288996-86-0

Basic information

• Product Name: 2-bromo-4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2Hpyran-2-yl)phenol
• Synonyms: 2-bromo-4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2Hpyran-2-yl)phenol
• CAS NO: 1288996-86-0
• Molecular Weight: 489.525
• Mol File: 1288996-86-0.mol

Chemical Properties

• CAS DataBase Reference: 2-bromo-4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2Hpyran-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2Hpyran-2-yl)phenol(1288996-86-0)
• EPA Substance Registry System: 2-bromo-4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2Hpyran-2-yl)phenol(1288996-86-0)

Safety Data

• Hazardous Substances Data: 1288996-86-0(Hazardous Substances Data)

Upstream product

• 1202784-98-2 (R)-2-[4-(tert-butyldimethylsilyloxy)phenethyl]-3,4-dihydro-2H-pyran 
• 1252036-60-4 3-bromo-4-hydroxybenzenediazonium tetrafluoroborate 

Downstream Products

• 1288996-92-8 2-bromo-4-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)phenol 

Relevant articles and documents

Pd-catalyzed arylation reactions with phenol diazonium salts: Application in the synthesis of diarylheptanoids

The first total synthesis of the natural product (3S,7R)-5,6-dehydro-de-O- methyl centrolobine and various analogues is reported, using a highly regio- and diastereoselective Mizoroki-Heck reaction of phenol diazonium salts and enantiopure dihydropyrans. The assigned relative configuration was confirmed by single-crystal X-ray structure analysis, but a revision of the absolute configuration is proposed based on polarimetric measurement.