1289023-68-2Relevant academic research and scientific papers
Asymmetric Synthesis of the Major Metabolite of a Calcitonin Gene-Related Peptide Receptor Antagonist and Mechanism of Epoxide Hydrogenolysis
Luo, Guanglin,Chen, Ling,Conway, Charles M.,Kostich, Walter,Johnson, Benjamin M.,Ng, Alicia,Macor, John E.,Dubowchik, Gene M.
, p. 3710 - 3720 (2017/04/11)
An asymmetric synthesis of the major metabolite of the calcitonin gene-related peptide recepotor antagonist BMS-846372 is presented. The variously substituted cyclohepta[b]pyridine ring system represents an underexplored ring system and showed some unexpe
CGRP RECEPTOR ANTAGONISTS
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, (2011/05/05)
The disclosure generally relates to the novel compounds of formula (I), including pharmaceutically acceptable salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).
