128911-31-9Relevant academic research and scientific papers
Reductive Cyclization of Carbon-Centered Glycine Radicals; A Novel Synthetic Route to Cyclic α-Amino Acids
Esch, Peter M.,Hiemstra, Henk,Boer, Richard F. de,Speckamp, W. Nico
, p. 4659 - 4676 (2007/10/02)
Reductive cyclizations (tributyltin hydride, AIBN) of several α-(phenylthio)glycine derivatives with a 3-alkenyl substituent at nitrogen are reported.These reactions proceed via 2-aza-5-alken-1-yl radicals as intermediates which bear electron-withdrawing
Synthesis of cyclic α-amino acids through ring closure of glycine derived free radicals
Esch, Peter M.,Hiemstra, Henk,Speckamp, W. Nico
, p. 759 - 762 (2007/10/02)
Cyclizations of 1-methoxycarbonyl-2-aza-5-hexenyl (and related) radical intermediates proceed in good yields and constitute a novel synthetic route to proline and pipecolic acid analogues.
