1289128-35-3

Upstream product

• 121-33-5 vanillin 
• 1258936-86-5 (2-bromo-3,4-dimethoxy-6-methylphenyl)-(2,3-dibromo-4,5-dimethoxyphenyl)-methanone 
• 6948-30-7 5-bromoveratralaldehyde 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 68278-85-3 3-bromo-4,5-dimethoxy-toluene 
• 70625-29-5 2,3-dibromo-4,5-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

PTP1B INHIBITORS, SYNTHESIS THEREOF AND APPLICATION THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING TYPE 2 DIABETES MELLITUS

The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.