128913-34-8Relevant academic research and scientific papers
Catalyst-Free Insertion of Sulfoxonium Ylides into Aryl Thiols. A Direct Preparation of β-Keto Thioethers
Dias, Rafael M. P.,Burtoloso, Antonio C. B.
, p. 3034 - 3037 (2016/07/06)
Insertion of sulfoxonium ylides into the S-H bond of aryl thiols without the need for a catalyst is demonstrated, furnishing β-keto thioethers in excellent yield in most cases. The method overcomes traditional syntheses that employ metal catalysts in combination with diazo compounds or toxic and hard-prepared haloketones. The experimental setup consists of mixing the reagents in acetonitrile at room temperature. Additional experimental as well as kinetic isotopic effect studies give some insight into the mechanism of this reaction.
Homochiral Group Transfer in Organic Synthesis via α-Diazocarbonyl Intermediates
Collins, Jeremiah C.,Dilworth, Bird M.,Garvey, Norah T.,Kennedy, Michael,McKervey, M. Anthony,O'Sullivan, Michael B.
, p. 362 - 364 (2007/10/02)
Optically active diazoketones derived from N-protected amino acids and (S)-2-chloropropionic acid have been used as homochiral group transfer reagents in the synthesis of various optically active α-functionalised ketones and related compounds.
