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Usage

Uses

Used in Pharmaceutical Research:
4-Bromo-2-isobutoxypyridine is utilized as a building block in pharmaceutical research for its unique structure and reactivity, which allows for the development of new pharmaceuticals with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 4-bromo-2-isobutoxypyridine is employed as a versatile intermediate, enabling the production of various organic compounds with a range of applications.
Used in Agrochemicals:
4-Bromo-2-isobutoxypyridine is also used in agrochemical research, where its unique properties can contribute to the development of new compounds for agricultural applications.
Used in Materials Science:
4-broMo-2-isobutoxypyridine's reactivity and structure make it a valuable component in materials science, where it can be used to create new materials with specific properties for various applications.

Upstream product

• 78-77-3 Isobutyl bromide 

Relevant academic research and scientific papers

Ligand Specific Efficiency (LSE) Index for PET Tracer Optimization

Ligand efficiency indices are widely used to guide chemical optimization in drug discovery, due to their predictive value in the early steps of optimization. At later stages, however, as more complex properties become critical for success, indices relying on calculated, rather than experimental, parameters become less informative. This problem is particularly acute when developing positron emission tomography (PET) imaging agents, for which nonspecific binding (NSB) to membranes and non-target proteins is a frequent cause of failure. NSB cannot be predicted using in silico parameters. To address this gap, we explored the use of the experimentally determined chromatographic hydrophobicity index on immobilized artificial membranes, CHI(IAM), to guide the optimization of NSB. The ligand specific efficiency (LSE) index was defined as the ratio between affinity (pIC50or pKd) and the logarithmic value of CHI(IAM). It allows for quantification of binding affinity to the target of interest, relative to NSB. Its use was illustrated by the optimization of PET tracer candidates for the prostacyclin receptor.