1289141-95-2

Basic information

• Product Name: C₁₉H₁₇NO₂
• CAS NO: 1289141-95-2
• Molecular Weight: 291.349
• Mol File: 1289141-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₇NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₇NO₂(1289141-95-2)
• EPA Substance Registry System: C₁₉H₁₇NO₂(1289141-95-2)

Safety Data

• Hazardous Substances Data: 1289141-95-2(Hazardous Substances Data)

Upstream product

• 122775-34-2 3-iodo-chromen-4-one 
• 229009-41-0 (4-(pyrrolidin-1-yl)phenyl) boronic acid 

Downstream Products

• 1289141-71-4 C₂₀H₂₀N₄O 

Relevant articles and documents

Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors

Figure Presented. Members of a series of 2,4,5-substituted pyrimidine derivatives were synthesized, and their interactions with tubulin and their antiproliferative activities against the human hepatocellular carcinoma cells of liver (BEL-7402) were evaluated. One member of this family, the indole-pyrimidine 4k, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC50 = 0.79 μM) and to display significantly high antiproliferative activities against several cancer cell lines with IC 50 values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G2/M phase of the cell cycle (EC50 = 20 nM). In addition, 4k was found to competitively inhibit colchicine binding to tubulin, indicating that it binds to the colchicine-binding site of tubulin. The observations made in this investigation demonstrate that 2,4,5-substituted pyrimidines represent a new class of tubulin polymerization inhibitors with significant antiproliferative activity.