1289178-50-2

Upstream product

• 171723-80-1 1-benzyl-4-piperidylbiphenyl-2-ylcarbamate 
• 171722-92-2 4-piperidyl N-(2-biphenyl)carbamate 
• 17337-13-2 [1,1'-biphenyl]-2-yl-isocyanate 
• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 1309750-56-8 C₂₅H₃₄N₂O₃ 

Downstream Products

• 743461-67-8 biphenyl-2-ylcarbamic acid 1-{7-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]heptyl}piperidin-4-yl ester 

Relevant academic research and scientific papers

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

We sought to design dual pharmacology bronchodilators targeting both the M3 muscarinic acetylcholine and beta-2 adrenergic (β2) receptors by applying our multivalent approach to drug discovery. Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.