1289191-99-6

Basic information

• Product Name: C-(2-Chloro-pyriMidin-5-yl)-MethylaMine
• Synonyms: C-(2-Chloro-pyriMidin-5-yl)-MethylaMine;2-Chloro-5-pyriMidineMethanaMine hydrochloride;(2-chloropyrimidin-5-yl)methanamine hydrochloride
• CAS NO: 1289191-99-6
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.57424
• Mol File: 1289191-99-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: C-(2-Chloro-pyriMidin-5-yl)-MethylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: C-(2-Chloro-pyriMidin-5-yl)-MethylaMine(1289191-99-6)
• EPA Substance Registry System: C-(2-Chloro-pyriMidin-5-yl)-MethylaMine(1289191-99-6)

Safety Data

• Hazardous Substances Data: 1289191-99-6(Hazardous Substances Data)

Upstream product

• 1046816-75-4 2-chloro-5-hydroxymethyl-pyrimidine 
• 22536-61-4 2-chloro-5-methylpyrimidine 
• 153281-13-1 5-(bromomethyl)-2-chloropyrimidine 

Downstream Products

• 754165-23-6 C₆H₆N₄ 

Relevant articles and documents

METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS

The present disclosure relates to compositions and methods for the treatment of diseases or disorders (e.g., cancer) with bi-steric inhibitors of mTOR in combination with RAS inhibitors. Specifically, in some embodiments this disclosure includes compositions and methods for inducing apoptosis of tumor cells and/or for delaying, preventing, or treating acquired resistance to RAS inhibitors using bi-steric mTOR inhibitors.

C26-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS

The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.