128924-77-6

Basic information

• Product Name: C₁₄H₁₁ClN₂O₅S
• Synonyms: C₁₄H₁₁ClN₂O₅S
• CAS NO: 128924-77-6
• Molecular Weight: 354.771
• Mol File: 128924-77-6.mol

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₁ClN₂O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₁ClN₂O₅S(128924-77-6)
• EPA Substance Registry System: C₁₄H₁₁ClN₂O₅S(128924-77-6)

Safety Data

• Hazardous Substances Data: 128924-77-6(Hazardous Substances Data)

Upstream product

• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 5769-15-3 4-Chlorophenylsulfonyl isocyanate 

Relevant articles and documents

Novel agents effective against solid tumors: The diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships

A series of diarylsulfonylureas with exceptionally broad-spectrum activity against syngeneic rodent solid tumors in vivo is described. Their discovery resulted from a program dedicated to in vivo screening for novel oncolytics in solid tumor models, rather than traditional ascites leukemia models. The structures, oral efficacy, side-effect profile, and mechanism of action of these sulfonylureas appear to be distinct from previously known classes of oncolytics. An extensive series of analogues was prepared to probe structure-activity relationships (SAR), with particular focus on the substituent patterns of each aryl domain. Quantitative analysis of these substituent SARs, using the method of cluster significance analysis, showed the lipophilicity of the substituents to be the dominant determinant of activity. One compound from the series, LY186641 (104, sulofenur), has progressed to Phase I clinical trials as an antitumor drug.