128948-45-8Relevant academic research and scientific papers
Amic acid derivative as well as preparation method and application thereof
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Paragraph 0117; 0156-0157; 0160; 0167, (2021/09/21)
The invention provides an amine acid derivative as well as a preparation method and application thereof. The amine acid derivative has the structure as follows. Herein, R is selected from methyl, methoxy and the like. R1 Selected from C1 - C4 a
Preparation method of tenuazonic Acid and derivative thereof
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Paragraph 0121-0122, (2021/05/12)
The invention provides a preparation method of tenuazonic Acid and a derivative thereof. The synthesis route comprises the following steps: reacting malonic acid cycloisopropylidene ester with acyl chloride, then reacting with amino acid methyl ester hydr
Tetramic Acid Chemistry. Part 1. Reinvestigation of Racemisation during the Synthesis of Tetramic Acids via Dieckmann Cyclisation
Poncet, Joel,Jouin, Patrick,Castro, Bertrand,Nicolas, Louisette,Boutar, Mohamed,Gaudemer, Alain
, p. 611 - 616 (2007/10/02)
Epimerisation during the synthesis of tetramic acids by Dieckmann cyclisation of the corresponding chiral N-acyl-α-amino esters was investigated.In the case of the isoleucine derivative, the extent of epimerisation was directly evaluated by 1H NMR analysis of the 3-acylated tetramic acids (3a,b) and (5a).A chemical correlation was carried out in the case of the 5-benzyl derivative (8h).The moderate overall yield and the partial epimerisation at position C-5 limit the usefulness of this approach for tetramic acid preparation.
