1289514-24-4

Usage

Uses

Used in Pharmaceutical Industry:
N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-Thiourea is used as a potential drug candidate for its possible biological activity. N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-Thiourea's unique structure may contribute to its efficacy in treating various medical conditions, although further research is needed to determine its specific applications and therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, N-[3,5-bis(trifluoroMethyl)phenyl]-N'-[(1R,2R)-2-(1-piperidinyl)cyclohexyl]-Thiourea may be utilized as a potential active ingredient in the development of new pesticides or herbicides. Its complex molecular structure could offer novel modes of action, potentially leading to more effective and targeted agricultural products. However, additional research is required to assess its suitability and safety for use in this context.

Upstream product

• 111-30-8 Glutaraldehyde 
• 885677-91-8 (1R,2R)-N¹-piperidinyl-1,2-diaminocyclohexane 
• 23165-29-9 3,5-bistrifluoromethylphenylisothiocyanate 
• 2163-28-2 trans-2-Cyclohexyl-cyclohexylamin 

Relevant academic research and scientific papers

Organocatalytic Enantioselective Vinylogous Aldol Reaction of Allyl Aryl Ketones to Activated Acyclic Ketones

The first catalytic asymmetric vinylogous aldol reaction of activated allyls to activated acyclic ketones is disclosed. A variety of activated acyclic ketones, such as trifluoromethyl ketones, α-ketoesters, and α-keto phosphonates, were found to be involved forming diverse γ-selective aldol adducts with high enantioselectivities (up to >99% ee). The method provides an effective, general strategy to access valuable chiral electron-withdrawing group-substituted tertiary hydroxyl-based carboxylic acids.

Directing the Activation of Donor–Acceptor Cyclopropanes Towards Stereoselective 1,3-Dipolar Cycloaddition Reactions by Br?nsted Base Catalysis

The first stereoselective organocatalyzed [3+2] cycloaddition reaction of donor-acceptor cyclopropanes is presented. It is demonstrated that by applying an optically active bifunctional Br?nsted base catalyst, racemic di-cyano cyclopropylketones can be activated to undergo a stereoselective 1,3-dipolar reaction with mono- and polysubstituted nitroolefins. The reaction affords functionalized cyclopentanes with three consecutive stereocenters in high yield and stereoselectivity. Based on the stereochemical outcome, a mechanism in which the organocatalyst activates both the donor-acceptor cyclopropane and nitroolefin is proposed. Finally, chemoselective transformations of the cycloaddition products are demonstrated.

NEW PROCESS

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis