1289560-75-3

Upstream product

• 109-04-6 2-bromo-pyridine 
• 89818-46-2 phenyl 2-pyridyl sulphoxide 
• 6320-02-1 o-bromothiophenol 
• 1210812-23-9 2-(2-bromophenylsulfanyl)pyridine 

Downstream Products

• 1289560-44-6 butyl (E)-3-[3-bromo-2-(2-pyridylsulfinyl)phenyl]acrylate 

Relevant academic research and scientific papers

Palladium-Catalyzed Highly Regioselective ortho -Halogenation of 2-Pyridyl Sulfoxides

A palladium-catalyzed regioselective ortho -halogenation of 2-pyridyl sulfoxides via a C-H activation pathway has been reported. Under the conditions established, this reaction proceeded smoothly and could tolerate a variety of functional groups under mild conditions.

2-pyridyl sulfoxide: A versatile and removable directing group for the PdII-catalyzed direct C-H olefination of arenes

Removable and versatile: The 2-pyridylsulfinyl group has proved to be an efficient directing group in the PdII-catalyzed aryl ortho C-H olefination. This catalyst system enables the sequential double olefination to give asymmetrically di-ortho-functionalized arenes. The sulfinyl directing group can be easily cleaved, providing access to 1,3-disubstituted arenes, or transformed into a thiol group.