1289562-91-9Relevant academic research and scientific papers
Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: Orally active, long-acting analgesics
Ezzili, Cyrine,Mileni, Mauro,McGlinchey, Nicholas,Long, Jonathan Z.,Kinsey, Steven G.,Hochstatter, Dustin G.,Stevens, Raymond C.,Lichtman, Aron H.,Cravatt, Benjamin F.,Bilsky, Edward J.,Boger, Dale L.
, p. 2805 - 2822 (2011/06/24)
A series of α-ketooxazoles containing conformational constraints in the C2 acyl side chain of 2 (OL-135) were examined as inhibitors of fatty acid amide hydrolase (FAAH). Only one of the two possible enantiomers displayed potent FAAH inhibition (S vs R en
