1289575-96-7Relevant academic research and scientific papers
Isatin N-phenylsemicarbazone: Effect of substituents and concentration on anion sensing selectivity and sensitivity
Cig, Marek,Jakusov, Klaudia,Donovalov, Jana,Sz?cs, Vojtech,Gplovsk, Anton
, p. 54072 - 54079 (2015/01/09)
The effect of substituent and concentration on anion sensing selectivity and sensitivity of nine new easily synthesized isatin N-phenylsemicarbazone E-isomer sensors IIIa-XIa was investigated. The substantial difference between the association constants for IIIa-XIa interaction with strongly and weakly basic anions allows detection of F- or CH3COO- anions even at high weakly basic anion excess. Substitution in position 5- of the isatin ring and para-substitution on the phenyl ring in the phenylsemicarbazide chain influence sensor:anion complex stoichiometry and thus also sensor sensitivity. Detection limits of 3-4 × 10-7 mol dm-3 for F- and CH3COO- anions by sensors IVa and Va bearing electron-withdrawing substituents are among the lowest published detection limits for these anions in organic solvents. The high selectivity and sensitivity of sensor VIa allows confident F- detection at tolerated fluoride drinking-water level. The solution dilution leads to a dramatic change in sensor selectivity. Consequently, one E-isomer can be used to sense both strongly and weakly basic anions. On the other side, higher sensor solution concentrations increase the F- and CH3COO- anion detection range, similar to the additional Z-isomer utilization. This journal is
Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors
Kang, Iou-Jiun,Wang, Li-Wen,Hsu, Tsu-An,Yueh, Andrew,Lee, Chung-Chi,Lee, Yen-Chun,Lee, Ching-Yin,Chao, Yu-Sheng,Shih, Shin-Ru,Chern, Jyh-Haur
, p. 1948 - 1952 (2011/05/04)
A series of isatin-β-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.
