1289602-30-7Relevant academic research and scientific papers
Nitroaldol reaction of nitro[11C]methane to form 2-(hydroxymethyl)-2-nitro[2-11C]propane-1,3-diol and [ 11C]Tris
Kato, Koichi,Zhang, Ming-Rong,Minegishi, Katsuyuki,Nengaki, Nobuki,Takei, Makoto,Suzuki, Kazutoshi
, p. 140 - 144 (2011)
The nitroaldol reaction of nitro[11C]methane and formaldehyde, which yields 2-(hydroxymethyl)-2-nitro[2-11C]propane-1,3-diol, is explored. The fluoride-ion-assisted nitroaldol reaction using (C 4H9)4NF was rapid and provided the desired nitrotriol in more than 97% radiochemical conversion (decay-corrected) in 3 min at room temperature. Neither 2-nitro[2-11C]ethanol nor 2-nitro[2-11C]propane-1,3-diol was observed under the reaction conditions. The preparation of 2-amino-2-(hydroxymethyl)-[2-11C] propane-1,3-diol ([11C]Tris) was described, which was followed by the nitro-group reduction using NiCl2 and NaBH4 in aqueous MeOH. The decay-corrected radiochemical conversion to [11C]Tris was 68.0±6.5% in two steps. Copyright
