128963-05-3Relevant academic research and scientific papers
Transformation of Uridine Derivatives into Cytidines via Selective Amination
Krug, A.,Schmidt, S.,Lekschas, J.,Lemke, K.,Cech, D.
, p. 835 - 842 (2007/10/02)
The synthesis of some 5-fluorosubstituted cytidine 2 derivatives via amination of corresponding uridine derivatives 1 is described. 5-Substituted 4-tetrazolo pyrimidinone derivatives 5 are key intermediates in the procedure.The method used is extended to other fluorinated starting materials, e.g. fluorinated uridinedinucleotides 7 or 2'-deoxy-2'-fluorouridine 9.The fluoro containing products are easily available by fluorination with elemental fluorine or hydrogene fluoride.
