1289644-74-1Relevant academic research and scientific papers
A Multicatalytic Approach to the Hydroaminomethylation of α-Olefins
Hanna, Steven,Holder, Jeffrey C.,Hartwig, John F.
supporting information, p. 3368 - 3372 (2019/02/24)
We report an approach to conducting the hydroaminomethylation of diverse α-olefins with a wide range of alkyl, aryl, and heteroarylamines at relatively low temperatures (70–80 °C) and pressures (1.0–3.4 bar) of synthesis gas. This approach is based on sim
Selective N-alkylation of amines with alcohols by using non-metal-based acid-base cooperative catalysis
Du, Ya,Oishi, Shunsuke,Saito, Susumu
supporting information; experimental part, p. 12262 - 12267 (2011/11/29)
Learning to cooperate: A straightforward method for the selective N-mono- and dialkylation of amines with alcohols by means of non-metal-based catalysis promoted by TAPC is reported (see scheme). Selectivity of the N-mono- and dialkylation, substrate scope and functional-group tolerance are highlighted with respect to each amine (1° and 2°; aromatic and aliphatic) and alcohol (1°, 2° and 3°; benzylic and aliphatic) component. Copyright
Iron/amino acid catalyzed direct N-alkylation of amines with alcohols
Zhao, Yingsheng,Foo, Siong Wan,Saito, Susumu
supporting information; experimental part, p. 3006 - 3009 (2011/05/04)
(Chemical Equation Presented) Ironing it out: The straightforward N-alkylation using alcohols and iron/amino acid catalysis is described (see scheme). The reaction does not proceed by the conventional "borrowing hydrogen" mechanism, but appears to involve a substitution pathway (S N) at the sp3 carbon atom bearing the hydroxy group of the alcohol. Developing a catalyst that is effective at a near neutral pH was key to the successful N-alkylation.
