1289644-76-3Relevant academic research and scientific papers
Iron/amino acid catalyzed direct N-alkylation of amines with alcohols
Zhao, Yingsheng,Foo, Siong Wan,Saito, Susumu
supporting information; experimental part, p. 3006 - 3009 (2011/05/04)
(Chemical Equation Presented) Ironing it out: The straightforward N-alkylation using alcohols and iron/amino acid catalysis is described (see scheme). The reaction does not proceed by the conventional "borrowing hydrogen" mechanism, but appears to involve a substitution pathway (S N) at the sp3 carbon atom bearing the hydroxy group of the alcohol. Developing a catalyst that is effective at a near neutral pH was key to the successful N-alkylation.
