1289647-98-8Relevant articles and documents
Pharmacokinetic optimisation of novel indole-2-carboxamide cannabinoid CB1 antagonists
Cowley, Phillip M.,Baker, James,Buchanan, Kirsteen I.,Carlyle, Ian,Clark, John K.,Clarkson, Thomas R.,Deehan, Maureen,Edwards, Darren,Kiyoi, Yasuko,Martin, Iain,Osbourn, Dawn,Walker, Glenn,Ward, Nick,Wishart, Grant
, p. 2034 - 2039 (2011/05/02)
The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB1 receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB1 antagonist with high