128973-58-0Relevant academic research and scientific papers
(2R)-5-Alkyl-2-tert-butyl-6-methyl-4H-1,3-dioxin-4-ones as Intermediates for the Preparation of α,β,β-Trisubstituted β-Hydroxycarboxylic Acids from (R)-3-Hydroxybutyric Acid under Self-Regeneration of the Stereogenic Center
Amberg, Willi,Seebach, Dieter
, p. 2429 - 2438 (2007/10/02)
The exocyclic double bonds of the readily available (2R,6R)-5-alkylidene-2-tert-butyl-6-methyl-1,3-dioxan-4-ones (preceding paper) are shifted to the endocyclic position by treatment with Pd-C/H2 to give the dioxins 2-6 in overall yields of 40-60percent (
