128989-93-5

Upstream product

• 128989-92-4 diphenylmethyl 7α-phenylacetamido-3-t-butyldimethylsilyloxymethyl-3-cephem-4-carboxylate 
• 128989-86-6 diphenylmethyl 7β-(o-hydroxybenzylideneamino)-3-t-butyldimethylsiloxymethyl-3-cephem-4-carboxylate 
• 90467-27-9 diphenylmethyl 7β-(o-hydroxybenzylideneamino)-3-hydroxymethyl-3-cephem-4-carboxylate 
• 35246-64-1 7β-phenylacetamido-3-hydroxymethyl-3-cephem-4-carboxylic acid diphenylmethyl ester 

Downstream Products

• 36923-19-0 7β-phenylacetamido-3-cephem-4-carboxylic acid diphenylmethyl ester 
• 128989-85-5 potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate 
• 128989-95-7 diphenylmethyl 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate 
• 128989-94-6 diphenylmethyl 7α-phenylacetamido-3-hydroxyiminomethyl-3-cephem-4-carboxylate 

Relevant academic research and scientific papers

7 β-phenylacetylamino-3-no-3-cephem-4-carboxylic acid bisphenylmethyl method for preparing methyl

The invention provides a method for preparing a 7beta-phenylacetyl amino-3-free-3-cephem-4-carboxylic acid benzyl ester from 7beta-phenylacetyl amino-3-methylol-3-cephem-4-carboxylic acid benzyl ester by adopting a catalytic oxidation and catalytic formylation two-step method. The method disclosed by the invention has the characteristics of being available in raw materials, short in reaction step, mild in reaction condition, fewer in three wastes, good in purity of a target product, high in atom economy and the like.

Synthesis and β-lactamase inhibitory activity of 3-cyano-3-cephem derivatives

Two new 3-cyano-3-cephem derivatives, potassium 3-cyano-3-cephem-4-carboxylate (2) and potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate (3), were prepared from 7β-aminocephalosporanic acid. Compounds 2 and 3 showed only weak β-lactamase inhibitory activity in contrast to sodium 7α-[(1R)-1-hydroxyethyl]-3-cyano-3-cephem-4-carboxylate (1), indicating the important role of the 7α-(1-hydroxyethyl) substituent for β-lactamase inhibitory activity.