129-17-9

Basic information

• Product Name: Acid blue 1
• Synonyms: 1085blue;4,4’-di(diethylamino)-4’,6’-disulphotriphenylmethanolanhydride,sodiumsalt;abcolpatentbluevf;acidbrightazurez;acidbrilliantbluevf;acidbrilliantbluez;acidbrilliantskybluez;acidleatherbluev
• CAS NO: 129-17-9
• Molecular Formula: C₂₇H₃₁N₂O₆S₂*Na
• Molecular Weight: 566.66
• EINECS: 204-934-1
• Product Categories: Triphenylmethane
• Mol File: 129-17-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: >250°C
• Appearance: Dark bluish-green to dark purple/Crystalline Powder
• Density: 0.392[at 20℃]
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Storage temperature: no restrictions.
• Solubility: H2O: soluble1mg/mL
• Water Solubility: 1 g/20 mL (20 ºC)
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 13,9078
• BRN: 4108121
• CAS DataBase Reference: Acid blue 1(CAS DataBase Reference)
• NIST Chemistry Reference: Acid blue 1(129-17-9)
• EPA Substance Registry System: Acid blue 1(129-17-9)

Safety Data

• Hazard Codes: T
• Statements: 45
• Safety Statements: 24/25-53-45
• WGK Germany: 3
• RTECS: BP6830000
• Hazardous Substances Data: 129-17-9(Hazardous Substances Data)

Usage

Chemical Properties

greenish blue powder

Uses

Different sources of media describe the Uses of 129-17-9 differently. You can refer to the following data:
1. double labeled product for electron microscopy and fluorescence research
2. A polysulfated aromatic dye
3. Patent Blue VF has been used:in combination with 99mTc phytate to detect sentinel lymph node (SLN) in early stage cervical cancer patients.to detect heat shock protein (HSP) gp96 induced draining lymph nodes (LNs) in mice.to detect the effect of Asn-Gly-Arg (NGR)-tumor necrosis factor (TNF) on tumor perfusion in murine model.
4. Acid Blue 1 is an organic dye used in ink jet textile printing.

Preparation

4-Formylbenzene-1,3-disulfonic acid and N,N-diethylbenzenamine (2 Moore) condensation and oxidation, and then turn it into sodium salt.

General Description

Dark greenish-black powder.

Air & Water Reactions

Water soluble.

Fire Hazard

Flash point data for Acid blue 1 are not available; Acid blue 1 is probably combustible.

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

Patent Blue VF dye is a violet colored powder. It has been used in cosmetic coloring.

Properties and Applications

colourful green light blue. Dark blue powder. Soluble in water, room temperature without gathered tendency, soluble in ethanol is blue. The strong sulfuric acid are yellow brown, a golden diluted; In nitric acid in the dark yellow; The little blue water solution, add sodium hydroxide is blue, boiling with blue. In dyeing copper and iron ion to turn green dark, encounter chromium ion little influence. Good levelness. In acid dye bath dyeing wool, silk, wool dyed used for the blended fabric. Can be directly in wool, silk printing things. Can also be used in carbon paper, ink and color break, also can be used to dye the leather. Standard Light Fastness Soaping Persperation Fastness Oxygen bleaching Fastness to seawater Fading Stain Fading Stain Fading Stain ISO 2 2 3 3 1-2 2 2-3 1-2 AATCC 1 1-2 1-2 2 2 2 2-3 2-3

Standard

Light Fastness

Fading

Stain

ISO

2

AATCC

1

InChI:InChI=1/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-18-17-24(36(30,31)32)19-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1

Synthetic route

Alphazurine 2G (129-17-9) → patent blue VF sulfonyl chloride

Conditions	Yield
With trichlorophosphate at 0 - 20℃; for 72h; Inert atmosphere;	90%
With trichlorophosphate at 20℃; for 72h;

Alphazurine 2G (129-17-9) → sodium; 4-[(4-diethylamino-cyclohexa-2,5-dienylidene)-(4-diethylamino-phenyl)-methyl]-3-sulfo-benzenesulfonate

Conditions	Yield
In water Kinetics; Electrochemical reaction;

Alphazurine 2G (129-17-9) → C64H100N3O22PS2 (1310568-66-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: trichlorophosphate / 72 h / 20 °C 2: dmap; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere View Scheme

Alphazurine 2G (129-17-9) → C60H92N3O22PS2 (1310568-67-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: trichlorophosphate / 72 h / 20 °C 2: dmap; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere 3: trimethylsilyl bromide / dichloromethane / 20 °C View Scheme

Alphazurine 2G (129-17-9) → C43H64N6O12S2

Conditions	Yield
Multi-step reaction with 2 steps 1.1: trichlorophosphate / 72 h / 0 - 20 °C / Inert atmosphere 2.1: triethylamine; dmap / dichloromethane / 0.25 h / 0 °C / Inert atmosphere 2.2: 16 h / 0 - 20 °C / Inert atmosphere View Scheme

Alphazurine 2G (129-17-9) → 2C27H31N2O6S2(1-)*Ba(2+)

Conditions	Yield
With barium(II) chloride dihydrate In water at 50℃; for 2h; Inert atmosphere;

Downstream Products

• 1310568-67-2 C₆₀H₉₂N₃O₂₂PS₂ 
• 1310568-66-1 C₆₄H₁₀₀N₃O₂₂PS₂