1290078-26-0

Basic information

• Product Name: 3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromene-6-carbaldehyde
• Synonyms: 3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromene-6-carbaldehyde
• CAS NO: 1290078-26-0
• Molecular Weight: 294.307
• Mol File: 1290078-26-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromene-6-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromene-6-carbaldehyde(1290078-26-0)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromene-6-carbaldehyde(1290078-26-0)

Safety Data

• Hazardous Substances Data: 1290078-26-0(Hazardous Substances Data)

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 3328-73-2 4-hydroxy-5-methylisophthalaldehyde 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 95-48-7 ortho-cresol 

Downstream Products

• 1476068-41-3 2-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-3-methyl-2, 3-dihydroquinazolin-4(1H)-one 
• 1425492-74-5 (+/-)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1425492-73-4 (±)-ethyl 4-(3-(4-methoxyphenyl)-8-methyl-2-oxo-2H-chromen-6-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant articles and documents

Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents

A series of amine substituted 3-phenyl coumarin derivatives were designed and synthesized as potential antidepressant agents. In preliminary screening, all compounds were evaluated in forced swimming test (FST), a model to screen antidepressant activity i

Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy

In this study, we presented rational designing and synthesis of coumarin-dihydroquinazolinone conjugates to evaluate their agonist activity at GPR109a receptor. Among the synthesized small molecule library, compound 10c displayed robust agonist action at

Hybrids of coumarin-indole: Design, synthesis and biological evaluation in Triton WR-1339 and high-fat diet induced hyperlipidemic rat models

In this study, a series of coumarin-indole hybrids have been synthesized and evaluated for their lipid lowering activity. Preliminary biological screening of the synthesized compounds was undertaken in an in vitro model of the HMG-CoA reductase enzyme, an

Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity

A new series of coumarin based aminopyran derivatives were designed, synthesized and evaluated for their preclinical antidepressant effect on Swiss albino mice. Among the series, compounds 21, 25, 26, 27, 32 and 33 exhibited significant activity profile i

Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent

Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol

Efficient and general synthesis of 3-aryl coumarins using cyanuric chloride 1

An efficient and general protocol for a rapid synthesis of different substituted 3-aryl coumarins is reported. A series of different substituted phenyl acetic acids have been successfully reacted with different substituted 2-hydroxy benzaldehydes in the presence of cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) and N-methyl morpholine to afford 3-aryl coumarins in good to excellent yields. Georg Thieme Verlag Stuttgart · New York.

Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents

A series of 3-phenylcoumarins were synthesized and screened for potential antidepressant activity by tail suspension test (TST) in mice. Three compounds (6, 7 and 13) exhibited impressive antidepressant activity, measured in terms of percentage decrease i