129010-60-2Relevant academic research and scientific papers
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors
Pechulis, Anthony D.,Beck, James P.,Curry, Matt A.,Wolf, Mark A.,Harms, Arthur E.,Xi, Ning,Opalka, Chet,Sweet, Mark P.,Yang, Zhicai,Vellekoop, A. Samuel,Klos, Andrew M.,Crocker, Peter J.,Hassler, Carla,Laws, Mia,Kitchen, Douglas B.,Smith, Mark A.,Olson, Richard E.,Liu, Shuang,Molino, Bruce F.
, p. 7219 - 7222 (2013/01/15)
Novel 4-phenyl tetrahydroisoquinolines that inhibit both dopamine and norepinephrine transporters were designed and prepared. In this Letter, we describe the synthesis, in vitro activity and associated structure-activity relationships of this series. We also report the ex vivo NET occupancy of a representative compound, 41.
8-AMINO-4-ARYL-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINES: REACTIONS OF THE AMINO GROUP VIA THE DIAZONIUM SALTS
Zara-Kaczian, Erzsebet,Deak, Gyula,Gyoergy, Lajos
, p. 573 - 590 (2007/10/02)
The amino group of 8-amino-4-aryl-2-methyl-1,2,3,4-tetrahydroisoquinolines(1) was exchanged for other groups via the diazonium salts.Thus from the diazonium-bis salt (2) of compound 1 the 8-fluoro- (3) and 8-nitro- (4) derivatives of 4-
