129012-03-9

Upstream product

• 67563-09-1 2-(4-methoxyphenyl)benzoxazole-6-carboxaldehyde 
• 126824-12-2 2,3-diamino-6-(4-methyl-1-piperazinyl) pyridine 
• 134577-44-9 3-Amino-6-(4-methyl-piperazin-1-yl)-pyridin-2-ol 
• 126824-22-4 2-(4-methoxyphenyl)-1H-benzo[d]imidazole-6-carbaldehyde 
• 127866-83-5 6-hydroxymethyl-2-(4-methoxyphenyl)benzoxazole 
• 127866-82-4 ethyl 2-(4-methoxyphenyl)benzoxazole-6-carboxylate 

Relevant academic research and scientific papers

A convenient synthesis of substituted oxazolo-[5,4-b]pyridines using lead tetraacetate as oxidative cyclizing agent

Various substituted oxazolo[5,4-b]pyridines 5a-d have been synthesized by condensation of appropriate hydroxyaminopyridines and aldehydes followed by oxidative cyclization of the resulting Schiff's bases with lead tetraacetate. This method has been extended to the synthesis of the DNA minor groove binding ligands 5e and 5f related to Hoechst 33258 1.

Convenient Routes to Substituted Benzimidazoles and Imidazolopyridines Using Nitrobenzene as Oxidant

Various substituted benzimidazoles and imidazolopyridines 5a-c have been prepared by condensation of appropriate diamines and aldehydes in nitrobenzene.This method has been utilized to synthesize compounds 5f-h, which are analogues of the DNA binding fluorochrome Hoechst 33258.