129012-22-2Relevant articles and documents
INTRAMOLECULAR CONDENSATION OF STEROIDAL 17α-FORMYL 17β-ACETATES: SYNTHESIS OF 14-FUNCTIONALISED 17-SPIROLACTONES
Bull, James R.,Steer, Lynne M.,Dillen, Jan L. M.
, p. 5401 - 5412 (2007/10/02)
17β-Acetoxy-3-methoxyestra-1,3,5(10)-triene-14,17α-dicarbaldehyde (1) undergoes base-mediated intramolecular condensation to give a mixture of the (141R)- and (141S)-141,20-hemiacetals of (20R)-14-formyl-20-hydroxy-3-methoxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17-carbolactone (2).The synthesis of derived 19-nor-17-spirolactones is described, and it is shown that 14-functionality participates in unusual intramolecular rearrangements.
Intramolecular condensation of steroidal 17α-formyl-17β-acetates: Synthesis of 14-hydroxymethyl-3-oxo-19-nor-17α-pregn-4-ene-21,17-carbolactone
Bull,Steer
, p. 6907 - 6910 (2007/10/02)
Intramolecular condensation of steroidal 17β-acetoxy-17α-carbaldehydes offers a synthetic route to 19-nor-17,17-spirolactones