129012-22-2

Upstream product

• 108-24-7 acetic anhydride 
• 129012-21-1 (20R)-20-Hydroxy-14-hydroxymethyl-3-methoxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17-carbolactone 
• 104512-90-5 14,17α-Diformyl-3-methoxy-14α-estra-1,3,5(10)-trien-17β-yl acetate 
• 129012-26-6 (14¹R/S)-14¹,20-Hemiacetals of (20R)-14-Formyl-20-hydroxy-3-methoxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17-carbolactone 
• 129012-26-6 C₂₃H₂₈O₅ 

Downstream Products

• 129012-23-3 14-Acetoxymethyl-3-methoxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17-carbolactone 
• 130917-62-3 14-Hydroxymethyl-3-methoxy-19-nor-17α-pregna-1,3,5(10),20-tetraene-21,17-carbolactone 

Relevant academic research and scientific papers

INTRAMOLECULAR CONDENSATION OF STEROIDAL 17α-FORMYL 17β-ACETATES: SYNTHESIS OF 14-FUNCTIONALISED 17-SPIROLACTONES

17β-Acetoxy-3-methoxyestra-1,3,5(10)-triene-14,17α-dicarbaldehyde (1) undergoes base-mediated intramolecular condensation to give a mixture of the (141R)- and (141S)-141,20-hemiacetals of (20R)-14-formyl-20-hydroxy-3-methoxy-19-nor-17α-pregna-1,3,5(10)-triene-21,17-carbolactone (2).The synthesis of derived 19-nor-17-spirolactones is described, and it is shown that 14-functionality participates in unusual intramolecular rearrangements.

Intramolecular condensation of steroidal 17α-formyl-17β-acetates: Synthesis of 14-hydroxymethyl-3-oxo-19-nor-17α-pregn-4-ene-21,17-carbolactone

Intramolecular condensation of steroidal 17β-acetoxy-17α-carbaldehydes offers a synthetic route to 19-nor-17,17-spirolactones