1290128-90-3

Upstream product

• 1290128-72-1 1-tert-butyl 5-ethyl 4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-1,5-dicarboxylate 
• 1290128-73-2 1-tert-butyl 5-ethyl 4-methyl-2-methylsulfanyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1290128-81-2 1-tert-butyl 5-ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1290128-98-1 ethyl 2-benzyloxyamino-4-methyl-1,6-dihydropyrimidine-5-carboxylate hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 159582-41-9 6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines

Synthesis of novel 4-unsubstituted dihydropyrimidines (DPs) was performed. Subsequently, a variety of 4-unsubstituted 1,4(3,4)-DPs with amino moieties at position-2 were obtained in excellent yields by activation of position-2 owing to regioselective alkoxycarbonylation at position-3 of the DP skeleton. 3-Oxo-2-phenyl-2,3,5,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrimidine was obtained using phenylhydrazine instead of amines. Individual tautomers of 1,4(3,4)-DP were observed in the 1H NMR spectra of one derivative depending on temperature and concentration. On the other hand, only 1,4-DP was found in the solid state by single-crystal X-ray crystallography.