1290629-81-0

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 1290629-79-6 [(2R,3R,4R,5S,6S)-3,4,5-trisbenzyloxy-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]benzenyl]tetrahydropyran-2-yl]methanol 
• 50-00-0 formaldehyd 
• 1290629-80-9 (2S,3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]tetrahydropyran-2-carbaldehyde 
• 1290629-78-5 (2S,3S,4R,5R,6R)-3,4,5-tris-benzyloxy-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6-trityloxymethyl-tetrahydro-pyran 
• 1290629-77-4 (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6-trityloxymethyl-tetrahydro-pyran-3,4,5-triol 

Downstream Products

• 1290630-10-2 {(3S,4R,5S,6S)-3,4,5-tris-benzyloxy-6-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-2-methyl-tetrahydro-pyran-2-yl}-methanol 
• 1290630-11-3 (3S,4R,5R,6S)-6-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-2-hydroxymethyl-2-methyl-tetrahydro-pyran-3,4,5-triol 
• 1290630-16-8 (6S,7S,8R,9S)-7,8,9-tris-benzyloxy-6-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-2,5-dioxa-spiro[3.5]nonane 
• 1221496-17-8 (6S,7R,8R,9S)-6-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-2,5-dioxa-spiro[3.5]nonane-7,8,9-triol 
• 1290630-18-0 acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-trifluoromethanesulfonyloxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-ylester. 
• 1290630-19-1 (5S,6S,7R,8S)-5-(4-chloro-3-(4-(pyrrolidin-1-yl)benzyl)phenyl)-4-oxaspiro[2.5]octane-6,7,8-triyl triacetate 
• 1290630-20-4 (5S,6R,7R,8S)-5-[4-chloro-3-(4-pyrrolidin-1-yl-benzyl)-phenyl]-4-oxa-spiro[2.5]octane-6,7,8-triol 
• 1290630-23-7 acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-3-nitro-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester 
• 1290630-24-8 {4-[2-chloro-5-((5S,6S,7R,8S)-6,7,8-triacetoxy-4-oxa-spiro[2.5]oct-5-yl)-benzyl]-2-nitro-phenoxy}-acetic acid ethyl ester 
• 1290629-72-9 acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester 
• 1290629-73-0 acetic acid (5S,6S,7R,8S)-7,8-diacetoxy-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-6-yl ester 
• 1290629-74-1 (5S,6R,7R,8S)-5-[4-chloro-3-(4-hydroxy-benzyl)-phenyl]-4-oxa-spiro[2.5]octane-6,7,8-triol 
• 1290629-75-2 (5S,6S,7R,8S)-5-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-4-oxaspiro[2.5]octane-6,7,8-triyl triacetate 
• 1290629-76-3 (5S,6S,7R,8S)-5-(4-chloro-3-{4-[(S)-(tetrahydro-furan-3-yl)oxy]-benzyl}phenyl)-4-oxaspiro[2.5]octane-6,7,8-triol 

Relevant academic research and scientific papers

Glucopyranosyl derivative, its preparation process and its use in medicine

Disclosed are a substituted pyranol derivative with sodium dependent glucose transporters (SGLTs) inhibitor compound 4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl, a preparation method thereof, and a pharmaceutical application thereof; and particularly a pyranol derivative expressed in formula I, a pharmaceutically acceptable salt thereof or all stereo isomers thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative as well as application thereof in treating diabetes and diabetes related diseases. The definitions of the substituent groups in formula I are the same as the definitions in the specification.

GLYCOSIDE DERIVATIVE AND USES THEREOF

This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

GLYCOSIDE DERIVATIVE AND USES THEREOF

This invention relates to compounds represented by formula (I) wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.