1290631-76-3Relevant academic research and scientific papers
Borane-catalyzed selective hydrosilylation of internal ynamides leading to β-silyl (Z)-enamides
Kim, Youngchan,Dateer, Ramesh B.,Chang, Sukbok
, p. 190 - 193 (2017/11/27)
We have developed a borane-catalyzed regioand stereoselective hydrosilylation of internal ynamides for the first time. The scope of ynamide substrates and silane reactants was broad under mild reaction conditions, affording synthetically versatile β-silyl (Z)-enamide products. The observed stereoselectivity was reasoned to be due to the β-silicon effect on a postulated ketene iminium intermediate.
Enantioselective ficini reaction: Ruthenium/PNNP-catalyzed [2+2] cycloaddition of ynamides with cyclic enones
Schotes, Christoph,Mezzetti, Antonio
supporting information; experimental part, p. 3072 - 3074 (2011/04/24)
(Chemical Equation Presented) Chiral cyclobuteneamides made easy: Double chloride abstraction from the ruthenium/PNNP complex 1 in the presence of unsaturated β-keto esters 2 gives the dicationic adducts [Ru(2)(PNNP)] 2+ (3) that catalyze the [2+2] cycloaddition of a variety of ynamides 4 to produce cyclo-buteneamides 5 with high yield and enantioselectivity (see scheme).
