1290631-83-2

Upstream product

• 66684-39-7 (bromoethynyl)cyclohexane 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 1116153-61-7 N-benzyl-N-(cyclohexylethynyl)-4-methylbenzenesulfonamide 

Downstream Products

• 1290632-00-6 (1S,4R,1'R,2'S, 5'S)-camphanic acid 7'-[N-benzyl-4-methylphenylsulfonamido]-1'-tert-butoxycarbonyl-6'-cyclohexylbicyclo[3.2.0]hept-6'-ene-2'-yl ester 
• 1375101-81-7 tert-butyl (1R,5S)-7-(N-benzyl-4-methylphenylsulfonamido)-2-[(tert-butyldimethylsilyl)oxy]-6-cyclohexylbicyclo[3.2.0]hepta-2,6-diene-1-carboxylate 
• 1375102-00-3 N-benzyl-N-[(1S,4S,5S)-7-cyclohexyl-4-[(dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy]-5-{[(dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy]methyl}bicyclo[3.2.0]hept-6-en-6-yl]-4-methylbenzenesulfonamide 
• 1375101-99-7 C₂₈H₃₃NO₄S 
• 1375101-98-6 N-benzyl-N-[(1S,4S,5S)-7-cyclohexyl-4-hydroxy-5-(hydroxymethyl)bicyclo[3.2.0]hept-6-en-6-yl]-4-methylbenzenesulfonamide 
• 1375101-92-0 tert-butyl (1R,2S,5S)-7-(N-benzyl-4-methylphenylsulfonamido)-6-cyclohexyl-2-[(dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy]bicyclo[3.2.0]hept-6-ene-1-carboxylate 
• 1375101-94-2 tert-butyl (1R,2S,5S)-7-(N-benzyl-4-methylphenylsulfonamido)-6-cyclohexyl-2-[(1,3,2-dioxaphospholan-2-yl)oxy]bicyclo[3.2.0]hept-6-ene-1-carboxylate 
• 1375101-85-1 tert-butyl (1R,2S,5S)-7-(N-benzyl-4-methylphenylsulfonamido)-6-cyclohexyl-2-hydroxy-2-methylbicyclo[3.2.0]hepta-3,6-diene-1-carboxylate 
• 1375101-83-9 tert-butyl (1R,5S)-7-(N-benzyl-4-methylphenylsulfonamido)-6-cyclohexyl-2-oxobicyclo[3.2.0]hepta-3,6-diene-1-carboxylate 
• 1290632-01-7 tert-butyl (1R,2S,5S)-7-(N-benzyl-4-methylphenylsulfonamido)-6-cyclohexyl-2-hydroxybicyclo[3.2.0]hept-6-ene-1-carboxylate 
• 1375102-02-5 tert-butyl (1R,5S)-7-(N-benzyl-4-methylphenylsulfonamido)-6-cyclohexyl-2-oxo-3-(phenylselanyl)bicyclo[3.2.0]hept-6-ene-1-carboxylate 

Relevant academic research and scientific papers

Enantioselective ficini reaction: Ruthenium/PNNP-catalyzed [2+2] cycloaddition of ynamides with cyclic enones

(Chemical Equation Presented) Chiral cyclobuteneamides made easy: Double chloride abstraction from the ruthenium/PNNP complex 1 in the presence of unsaturated β-keto esters 2 gives the dicationic adducts [Ru(2)(PNNP)] 2+ (3) that catalyze the [2+2] cycloaddition of a variety of ynamides 4 to produce cyclo-buteneamides 5 with high yield and enantioselectivity (see scheme).

Bicyclo[3.2.0]heptane-based enamides by Ru/PNNP-catalyzed enantioselective ficini reactions: Scope and application in ligand design

Double chloride abstraction from [RuCl2(PNNP)] [PNNP- = (S,S)-N,N-bis[o-(diphenylphosphino)benzylidene]cyclohexane-1,2-diamine] gives the elusive dicationic adduct [Ru(OEt)2(PNNP)]2+ which catalyzes the [2+2] cycloaddition