129077-03-8

Upstream product

• 142794-45-4 1-{(2R,3aS,9aR)-3-[(E)-Hydroxyimino]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 129076-82-0 1-{(2R,3aS,9aR)-3-[(E)-Hydroxyimino]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 89-98-5 2-chloro-benzaldehyde 

Relevant academic research and scientific papers

NOVEL TYPES OF CYCLONUCLEOSIDES

Reduction of 2'-deoxy-2'-hydroxyiminouridine derivatives led to a "first generation" hydroxylamine (2'-deoxy-2'-hydroxyaminouridine 8, mostly arabino configuration) which on treatment with aldehydes afforded the corresponding nitrones 9 which were reduced to "second generation" hydroxylamines 12.The modified nucleosides bearing a hydroxylamino group at the 2'-position, when of arabino configuration underwent conjugate addition onto the uracil ring leading to novel types of cyclonucleosides (3,5,10,13).