129077-07-2

Basic information

• Product Name: (2R,3S,3aS,10aR)-4-(2-Chloro-benzyl)-3-hydroxy-2-hydroxymethyl-hexahydro-furo[2,3-c]pyrimido[1,6-e][1,2,5]oxadiazine-7,9-dione
• CAS NO: 129077-07-2
• Molecular Weight: 383.788
• Mol File: 129077-07-2.mol

Chemical Properties

• CAS DataBase Reference: (2R,3S,3aS,10aR)-4-(2-Chloro-benzyl)-3-hydroxy-2-hydroxymethyl-hexahydro-furo[2,3-c]pyrimido[1,6-e][1,2,5]oxadiazine-7,9-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,3aS,10aR)-4-(2-Chloro-benzyl)-3-hydroxy-2-hydroxymethyl-hexahydro-furo[2,3-c]pyrimido[1,6-e][1,2,5]oxadiazine-7,9-dione(129077-07-2)
• EPA Substance Registry System: (2R,3S,3aS,10aR)-4-(2-Chloro-benzyl)-3-hydroxy-2-hydroxymethyl-hexahydro-furo[2,3-c]pyrimido[1,6-e][1,2,5]oxadiazine-7,9-dione(129077-07-2)

Safety Data

• Hazardous Substances Data: 129077-07-2(Hazardous Substances Data)

Upstream product

• 142794-45-4 1-{(2R,3aS,9aR)-3-[(E)-Hydroxyimino]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 129076-82-0 1-{(2R,3aS,9aR)-3-[(E)-Hydroxyimino]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 89-98-5 2-chloro-benzaldehyde 

Relevant articles and documents

NOVEL TYPES OF CYCLONUCLEOSIDES

Reduction of 2'-deoxy-2'-hydroxyiminouridine derivatives led to a "first generation" hydroxylamine (2'-deoxy-2'-hydroxyaminouridine 8, mostly arabino configuration) which on treatment with aldehydes afforded the corresponding nitrones 9 which were reduced to "second generation" hydroxylamines 12.The modified nucleosides bearing a hydroxylamino group at the 2'-position, when of arabino configuration underwent conjugate addition onto the uracil ring leading to novel types of cyclonucleosides (3,5,10,13).