129081-64-7Relevant academic research and scientific papers
Decarboxylative Carbon Acylation of Malonates with Aminoacylimidazoles Mediated by Lewis Acids
Mansour, Tarek S.,Evans, Colleen A.
, p. 773 - 781 (2007/10/02)
Various N-protected aminoacylimidazoles undergo decarboxylative carbon acylation with sodium or potassium monomethylmalonate in THF in the presence of MgCl2, CoCl2 or MnCl2 to give dipeptide analogues (3) in 45-82percent isolated yield.Amino ketoester (3e) undergoes intramolecular cyclization induced by diisopropylethylamine and anhydrous magnesium chloride to trisubstituted tetramic acid (4).
