129095-53-0

Upstream product

• 96233-02-2 (R)-N-[(S)-1-phenylethyl]-2-chloro-2-fluoroethanamide 
• 96233-03-3 (S)-N-[(S)-1-phenylethyl]-2-chloro-2-fluoroethanamide 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 129172-17-4 (R)-N-[(S)-1-phenylethyl]-2-(1,3-dioxo-2-isoindolinyl)-2-fluoroethanamide 
• 126215-56-3 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-fluoro-N-((R)-1-phenyl-ethyl)-acetamide 
• 129172-16-3 (S)-N-[(S)-1-phenylethyl]-2-(1,3-dioxo-2-isoindolinyl)-2-fluoroethanamide 

Relevant academic research and scientific papers

Synthesis of α-heterosubstituted glycine derivatives from dihaloethanamides

A range of protected α-heterosubstituted analogues of glycine were synthesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I; R = CH2Ph, (s)-CHMePh]; the final products included derivatives of glycine possessing N, O, F or S in the α-position, and the first example of a free α-fluoro-α-amino acid (α-fluorobetaine) whose structure was confirmed by X-ray crystal structure determination.

Asymmetric synthesis of protected α-fluoroglycines

Single crystal x-ray structure determination of a key fluoroiodoacetamide gives access to protected α-fluoroglycines of known absolute stereochemistry.