1291056-45-5Relevant academic research and scientific papers
Facile Synthesis of Novel Vanillin Derivatives Incorporating a Bis(2-hydroxyethyl)dithhioacetal Moiety as Antiviral Agents
Zhang, Jian,Zhao, Lei,Zhu, Chun,Wu, Zengxue,Zhang, Guoping,Gan, Xiuhai,Liu, Dengyue,Pan, Jianke,Hu, Deyu,Song, Baoan
, p. 4582 - 4588 (2017)
A series of vanillin derivatives incorporating a bis(2-hydroxyethyl)dithioacetal moiety was designed and synthesized via a facile method. A plausible reaction pathway was proposed and verified by computational studies. Bioassay results demonstrated that target compounds possessed good to excellent activities against potato virus Y (PVY) and cucumber mosaic virus (CMV), of which, compound 6f incorporating a bis(2-hydroxyethyl)dithioacetal moiety, exhibited the best curative and protection activities against PVY and CMV in vivo, with 50% effective concentration values of 217.6, 205.7 μg/mL and 206.3, 186.2 μg/mL, respectively, better than those of ribavirin (848.0, 808.1 μg/mL and 858.2, 766.5 μg/mL, respectively), dufulin (462.6, 454.8 μg/mL and 471.2, 465.4 μg/mL, respectively), and ningnanmycin (440.5, 425.3 μg/mL and 426.1, 405.3 μg/mL, respectively). Current studies provide support for the application of vanillin derivatives incorporating bis(2-hydroxyethyl)dithioacetal as new antiviral agents.
Nickel(II) chloride hexahydrate catalyzed reaction of aromatic aldehydes with 2-mercaptoethanol: Formation of supramolecular helical assemblage of the product
Laskar, Rajibul A.,Begum, Naznin A.,Mir, Mohammad Hedayetullah,Rohman, Md. Rumum,Khan, Abu T.
, p. 5839 - 5844 (2013/10/21)
Various aromatic aldehydes on reaction with 2-mercaptoethanol provided an unanticipated product, bis(2-hydroxyethyl)dithioacetals (3) as the major product along with the expected product 1,3-oxathiolanes (4) in the presence of 0.05 equiv amount of nickel(
Nitroaromatic bis(2-hydroxyethyl)dithioacetals and oxathioacetals using 2-mercaptoethanol in the presence of chlorosilanes
Papernaya, Lyubov K.,Shatrova, Alexandra A.,Albanov, Alexander I.,Klyba, Lyudmila V.,Levkovskaya, Galina G.
experimental part, p. 173 - 184 (2012/04/18)
Thioacetalization of the nitrobenzaldehydes with 2-mercaptoethanol is easily carried out in the presence of TMSCl and dichlorodimethylsilane without heating and using of additional solvent. The reaction direction is defined by the reagents ratio and led t
