1291067-40-7

Upstream product

• 120-72-9 indole 
• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Host/guest inclusion system of surfactants with β-cyclodextrin as a viable catalyst for one-pot synthesis of mono- and bis (indolyl)methylmalononitriles in H2O

In this study, encapsulation processes of cetyltrimethylammonium bromide (CTAB) or sodium dodecyl sulfate (SDS) monomers into the cavity of β-cyclodextrin (β-CD) were applied to synthesize mono- and bis (indolyl)methylmalononitrile derivatives by a one-po

Green route for the synthesis of 3-substituted indoles using [bmim]HSO4 as non-halogenated ionic liquid

In this paper, an effective procedure is reported for the synthesis of 3-substituted indoles via the one-pot three-component reaction of an aldehyde, malononitrile or ethyl cyanoacetate and indole in the presence of [bmim]HSO4 in ethanol under

Morphology controlled phosphate grafted SnO2-ZrO2 nanocomposite oxides prepared by a urea hydrolysis method as efficient heterogeneous catalysts towards the synthesis of 3-substituted indoles

In this study, a series of phosphate grafted SnO2-ZrO2 nanocomposite oxides are prepared via the urea hydrolysis of salt precursors followed by treatment with phosphate ions and calcination. The nanocomposite materials are characteri

Facile synthesis of 3-substituted indoles containing highly polarized double bonds

In this paper, an effective procedure is described for the synthesis of novel indoles containing highly polarized double bonds. The strategy involves the preparation of (indolylmethyl)malononitriles via the one-pot three-component reaction of an aldehyde,

L - proline in catalytic multi-component generating 3 - substituted indole derivative use and method

The invention discloses application and a method of L-proline in catalyzing multiple components to generate a 3-substituted indole derivative. According to the method, under the catalysis of L-proline, a general formula 1, a general formula 2 and a compou

Efficient synthesis of 3-substituted indoles via a base-free copper-catalysed three-component reaction in water

The preparation of sixteen 3-substituted indoles in good to excellent yields under environmentally friendly conditions has been achieved via a three-component reaction in water of an indole, an aldehyde and malononitrile (or ethyl 2-cyanoacetate) catalysed by 5 mol% of 2-pyrrolecarbaldiminato-Cu(II).

L-Proline-catalyzed multicomponent synthesis of 3-indole derivatives

A green one-pot multicomponent reaction for the synthesis of 3-indole derivatives was developed via l-proline-catalyzed condensation between indoles, aldehydes, and malononitrile. The process was carried out in ethanol at room temperature, and the desired

[TBA][Gly] ionic liquid promoted multi-component synthesis of 3-substituted indoles and indolyl-4H-chromenes

Tetrabutylammonium glycinate [TBA][Gly] ionic liquid was found to be an efficient recyclable and biodegradable organocatalyst for selective synthesis of 3-substituted indoles and indolyl-4H-chromenes. The reaction between substituted aliphatic/aromatic aldehydes, malononitrile, and indoles in the presence of [TBA][Gly] IL at 60 °C under solvent free conditions afforded 3-substituted indoles in excellent yields. Indolyl-4H-chromenes were achieved in excellent yields by replacing the benzaldehydes with salicylaldehyde under optimized reaction conditions.

Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water

A sustainable three-component reaction of indoles, aldehydes, and malononitrile in water promoted by polyethylene glycol (PEG-200) afforded 3-indole derivatives in good to excellent yields.