129109-17-7

Basic information

• Product Name: METHYL 4-CHLORO-6-OXO-1-PHENYL-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE
• Synonyms: METHYL 4-CHLORO-6-OXO-1-PHENYL-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE;AURORA KA-3625;Methyl 4-chloro-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate
• CAS NO: 129109-17-7
• Molecular Formula: C₁₂H₉ClN₂O₃
• Molecular Weight: 264.66
• Mol File: 129109-17-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 104-106°C
• Boiling Point: 362.5°Cat760mmHg
• Flash Point: 173°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 1.93E-05mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 4-CHLORO-6-OXO-1-PHENYL-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-CHLORO-6-OXO-1-PHENYL-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE(129109-17-7)
• EPA Substance Registry System: METHYL 4-CHLORO-6-OXO-1-PHENYL-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE(129109-17-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 129109-17-7(Hazardous Substances Data)

Usage

General Description

Methyl 4-chloro-6-oxo-1-phenyl-1,6-dihydro-3-pyridazinecarboxylate is a chemical compound with the molecular formula C13H10ClNO3. This synthetic chemical is part of the pyridazine series, characterized by its six-membered molecular ring, containing four carbon atoms and two nitrogen atoms. The specific structure of this compound includes a chlorine atom, indicative in the "4-chloro" part of its name, and an oxygen atom as parts of its functional groups. Like many chemicals of its class, it could potentially be used in various fields such as medicine or agriculture, but specific examples of its usage or research about it are somewhat scarce due to its complex nature and specialized structure.

InChI:InChI=1/C12H9ClN2O3/c1-18-12(17)11-9(13)7-10(16)15(14-11)8-5-3-2-4-6-8/h2-7H,1H3

Upstream product

• 121582-53-4 methyl 2-phenyl-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylate 

Downstream Products

• 129109-30-4 5-n-Propylthio-6-methoxycarbonyl-2-phenylpyridazin-3(2H)-one 
• 129109-52-0 5-Hydrazino-6-methoxycarbonyl-2-phenylpyridazin-3(2H)-one 
• 129109-53-1 5-Hydrazino-3-oxo-2-phenyl-2,3-dihydropyridazine-6-carboxylic hydrazide 
• 129109-21-3 4-Azido-6-oxo-1-phenyl-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester 
• 129109-31-5 5-i-Propylthio-6-methoxycarbonyl-2-phenylpyridazin-3(2H)-one 
• 129109-35-9 5-Benzylthio-6-methoxycarbonyl-2-phenylpyridazin-3(2H)-one 
• 129109-29-1 5-Ethylthio-6-methoxycarbonyl-2-phenylpyridazin-3(2H)-one 
• 1398117-34-4 5-cyclohexylamino-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone 
• 1398116-99-8 N₂-iminomethyl-6-oxo-4-phenylsulfanyl-1-phenyl-1,6-dihydropyridazin-3-carbohydrazide 
• 1398117-39-9 5-phenoxy-2-phenyl-6-(5-methyl-1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone 
• 1398117-33-3 5-benzylamino-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone 
• 1398117-19-5 5-isopropylamino-2-phenyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone 
• 338405-12-2 N,N-dimethyl-N′-[(6-oxo-4-phenoxy-1-phenyl-1,6-dihydropyridazin-3-yl)carbonyl]formamidine 
• 1398117-07-1 2-phenyl-5-phenylsulfanyl-6-(1H-1,2,4-triazol-3-yl)-3(2H)-pyridazinone 

Relevant articles and documents

Heterocyclic inhibitors of MEK and methods of use thereof

Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.