1291103-22-4

Upstream product

• 1193-02-8 4-aminotiophenol 
• 284462-87-9 4-[(4-aminophenylthio)(2-pyridyl)]-N-methylcarboxamide 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel N-methyl-picolinamide-4-thiol derivatives as potential antitumor agents

A novel series of N-methylpicolinamide-4-thiol derivatives were synthesized and evaluated on human cancer cell lines. Among them, compound 6p displayed potent and broad-spectrum anti-proliferative activities in vitro on some human cancer cell lines, even better than sorafenib. The advanced kinase inhibitory assays showed that compound 6p could selectively inhibit Aurora-B kinase. The biological results were rationalized by the molecular docking study, which indicated the stable interactions of 6p with the Aurora-B kinase.