129111-69-9Relevant academic research and scientific papers
Trimethylacetamidomethyl (Tacm) group, a new protecting group for the thiol function of cysteine
Kiso,Yoshida,Fujiwara,Kimura,Shimokura,Akaji
, p. 673 - 675 (1990)
S-Trimethylacetamidomethyl-L-cysteine [Cys(Tacm)] was easily prepared from N-hydroxymethyltrimethyl-acetamide and L-cysteine in trifluoroacetic acid. The S-Tacm group is stable to HF, but cleavable with mercury(II) acetate in trifluoroacetic acid or iodine in aqueous acetic acid. Cys(Tacm) is less susceptible to sulfoxide formation than three related groups, i.e., acetamidomethyl (Acm), benzamidomethyl (Bam) and (2-oxo-1-pyrrolidinyl)methyl (Pym).
