129112-64-7

Basic information

• Product Name: 2-Chloro-7-nitro-3H-quinazolin-4-one
• Synonyms: 2-Chloro-7-nitro-3H-quinazolin-4-one
• CAS NO: 129112-64-7
• Molecular Formula: C₈H₄ClN₃O₃
• Molecular Weight: 225.58866
• Mol File: 129112-64-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-7-nitro-3H-quinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-7-nitro-3H-quinazolin-4-one(129112-64-7)
• EPA Substance Registry System: 2-Chloro-7-nitro-3H-quinazolin-4-one(129112-64-7)

Safety Data

• Hazardous Substances Data: 129112-64-7(Hazardous Substances Data)

Upstream product

• 129112-65-8 2,4-dichloro-7-nitroquinazoline 
• 174565-63-0 7-nitro-1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 619-17-0 4-Nitroanthranilic acid 

Downstream Products

• 129112-48-7 2-(4-Methyl-piperazin-1-yl)-7-nitro-4-phenoxy-quinazoline 
• 129112-50-1 2-(4-Methyl-piperazin-1-yl)-4-phenoxy-quinazolin-7-ylamine 
• 129112-52-3 7-Chloro-2-(4-methyl-piperazin-1-yl)-4-phenoxy-quinazoline 

Relevant articles and documents

Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments

Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC50 50 50 > 25 μM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies.

Novel 4-phenoxy-2-(1-piperazinyl)quinazolines as potent anticonvulsive and antihypoxic agents

A series of 4-phenoxy-2-(1-piperazinyl)quinazolines was synthesized and examined for anticonvulsive and antihypoxic activities. Many of the compounds exhibited potent anticonvulsive activity comparable to that of carbamazepine or phenytoin. Among them, 4-