129119-80-8

Basic information

• Product Name: 3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-(phenylmethyl)-5-(3-pyridinyl)-
• CAS NO: 129119-80-8
• Molecular Formula: C14H12N4S
• Molecular Weight: 268.342
• Mol File: 129119-80-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-(phenylmethyl)-5-(3-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-(phenylmethyl)-5-(3-pyridinyl)-(129119-80-8)
• EPA Substance Registry System: 3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-(phenylmethyl)-5-(3-pyridinyl)-(129119-80-8)

Safety Data

• Hazardous Substances Data: 129119-80-8(Hazardous Substances Data)

Upstream product

• 553-53-7 Nicotinic acid hydrazide 
• 622-78-6 Benzyl isothiocyanate 
• 100-46-9 benzylamine 
• 211572-59-7 N-benzyl-2-(pyridin-3-ylcarbonyl)hydrazinecarbothioamide 
• 3690-46-8 5-(3-pyridinyl)-1,3,4-oxadiazol-2-thiol 

Downstream Products

• 440638-21-1 (4-benzyl-5-(3-pyridyl)-4H-1,2,4-triazol-3-yl) ethyl sulfide 
• 257612-59-2 C₁₈H₁₈N₄O₂S 
• 1352049-52-5 2-[-4-benzyl-5-(3-pyridyl)-4H-1,2,4-triazole-3-ylthio]-N⁽²⁾-[1-methyl-3-oxobutilidin]acetohydrazine 
• 1352049-57-0 1-[(4-benzyl)-5-(3-pyridyl)-4H-1,2,4-triazol-3-ylthiomethylcarboxyl]-3,5-dimethyl-1H-pyrazole 
• 1352049-64-9 5-[4-benzyl-5-(3-pyridyl)-1,2,4-triazole-3-ylthiomethyl]-1,3,4-oxadiazole-2-thiol 
• 359010-76-7 C₁₆H₁₆N₆OS 

Relevant articles and documents

Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties

4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the presence of formaldehyde. The synthesis of S-alkylated compounds 8-11 was performed from the reaction of the corresponding triazol-5-thioles with various alkyl halides. The condensation of carbo(thio)amides 2-4 with 4-chlorophenacyl bromide afforded the corresponding 1,3-thia(oxa)zol-2(3H)-ylidene]pyridine-3- carbohydrazides 25-27. 1,3-Thia(oxa)zolidine derivatives 28-30 were obtained from the cyclization reaction between compounds 2-4 and ethyl bromoacetate. All newly synthesized compounds were screened for their antimicrobial, antiurease, and antilipase activities. The biological activity studies revealed that all the compounds screened showed good or moderate antimicrobial, antiurease, and/or antilipase activity.

Synthesis and structure determination of some oxadiazole-2-thione and triazole-3-thione galactosides

The syntheses of 5-pyridyl-3(β-D-galactopyranosyl)-1,3,4-oxadiazole-2-thiones 3a-3c and 5-pyridyl-2(β-D-galactopyranosyl)-4-benzyl-l,2, 4-triazole-3-thiones 6a-6c are reported. The existence of N-galactosides - not S-galactosides - was proven by IR and 15N NMR spectroscopy. The structures of the final products and the intermediates were elucidated by IR, 1H, 13C and 15N NMR spectroscopy and mass spectrometry.

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Dopamine-β-hydroxylase inhibitors of structure: in which R1 is pyridyl or pyridylalkyl, pharmaceutical compositions containing them and their use in therapy in lowering blood pressure.