129121-60-4Relevant academic research and scientific papers
Synthesis of frame-shifted farnesyl diphosphate analogs
Placzek, Andrew T.,Hougland, James L.,Gibbs, Richard A.
, p. 4038 - 4041 (2012)
A set of synthetic approaches were developed and applied to the synthesis of eight frame-shifted farnesyl diphosphate (FPP) analogs. These analogs bear increased or decreased methylene units between the double bonds and/or diphosphate moieties of the isop
Hydroxamic acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase
Patel, Dinesh V.,Young, Marian G.,Robinson, Simon P.,Hunihan, Lisa,Dean, Brenda J.,Gordon, Eric M.
, p. 4197 - 4210 (2007/10/03)
The rational design, synthesis, and activity of novel, hydroxamic acid- based, collective bisubstrate analog inhibitors of farnesyl protein transferase (FPT) is described. This class of compounds differ structurally from the conventional FPT inhibitors by
Farnesyl pyrophosphate analogs
-
, (2008/06/13)
The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the com
Phosphorus-containing squalene synthetase inhibitors
-
, (2008/06/13)
Compounds which are inhibitors of cholesterol biosynthesis (by inhibiting de novo squalene biosynthesis), and thus are useful as hypocholesterolemic agents and antiatherosclerotic agents are provided which have the structure STR1 wherein m is 0, 1, 2 or 3; n is 0, 1, 2, 3 or 4; Y1 and Y2 are H or halogen; R2, R3 and R4 may be the same or different and are independently H, metal ion, C1 to C8 alkyl or C3 to C12 alkenyl; X is O, S, NH or NCH2 R15 wherein R15 is H or C1 to C5 alkyl; and R1 is R5 --Q1 --Q2 --Q3 -- wherein R5, Q1, Q2 and Q3 are as defined herein; and when m is o, X is other than S; and if m is o and X is 0, then n is 1, 2, 3 or 4; including all stereoisomers thereof.
