129144-38-3Relevant academic research and scientific papers
Hypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones
Yoshimura, Akira,Jarvi, Melissa E.,Shea, Michael T.,Makitalo, Cody L.,Rohde, Gregory T.,Yusubov, Mekhman S.,Saito, Akio,Zhdankin, Viktor V.
, p. 6682 - 6689 (2019/11/02)
An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from respective aldoximes using hypervalent iodine reagents has been developed. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of the 3,4-disubstituted isoxazoles in moderate to good yields. Structures of several isoxazole products were confirmed by a single X-ray crystallography.
SYNTHESIS OF 4-ACYLISOXAZOLE-5-CARBOXYLATES VIA 1,3-DIPOLAR CYCLOADDITION REACTION OF β-ACYLPYRUVATES WITH NITRILE OXIDES IN THE ABSENCE OF BASE
Kim, Jae Nyoung,Ryu, Eung K.
, p. 663 - 670 (2007/10/02)
The fully substituted isoxazole derivatives 3 were prepared in moderate to high yields via the cycloaddition reaction of nitrile oxides with β-acylpyruvates 2. β-Acylpyruvates, unlikely ordinary β-diketones, show high dipolarophilic reactivity toward nitr
