1291486-24-2 Usage
Derivative of pyrrolidine
A modified version of the pyrrolidine structure A chemical compound that is based on the pyrrolidine ring, with alterations to its functional groups.
Reactive molecule
Tends to undergo chemical reactions easily 1-Methyl-5-oxopyrrolidine-3-carbonyl chloride is prone to participate in various chemical reactions due to its nature.
Electrophilic molecule
Attracts electron pairs in reactions The presence of the carbonyl chloride group makes the molecule attract electron pairs, which is useful for forming new bonds.
Carbonyl chloride group
Presence of a Cl-C(=O)group This functional group is responsible for the reactivity and electrophilic nature of the compound.
Introduction of pyrrolidine-3-carbonyl functionality
Incorporates the specific functional group into organic molecules The compound can be used to add the pyrrolidine-3-carbonyl group to other organic molecules, creating new compounds with desired properties.
Used in organic synthesis
A reagent for preparing various compounds 1-Methyl-5-oxopyrrolidine-3-carbonyl chloride is employed as a reagent in the synthesis of a wide range of organic compounds.
Applications in pharmaceutical and agrochemical industries
Synthesis of biologically active compounds The compound is utilized in the production of molecules with biological activity, such as drugs and pesticides.
Potential hazards
Reactivity can pose risks Due to its reactivity, 1-Methyl-5-oxopyrrolidine-3-carbonyl chloride can be hazardous, and special care should be taken when handling it.
Laboratory safety precautions
Should be handled and used with caution in a laboratory setting Proper safety measures and procedures must be followed to minimize risks when working with 1-Methyl-5-oxopyrrolidine-3-carbonyl chloride.
Check Digit Verification of cas no
The CAS Registry Mumber 1291486-24-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,1,4,8 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1291486-24:
(9*1)+(8*2)+(7*9)+(6*1)+(5*4)+(4*8)+(3*6)+(2*2)+(1*4)=172
172 % 10 = 2
So 1291486-24-2 is a valid CAS Registry Number.
1291486-24-2Relevant academic research and scientific papers
NOVEL COMPOUNDS
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, (2015/12/17)
Disclosed are novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.
CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives
Imamura, Shinichi,Ishihara, Yuji,Hattori, Taeko,Kurasawa, Osamu,Matsushita, Yoshihiro,Sugihara, Yoshihiro,Kanzaki, Naoyuki,Iizawa, Yuji,Baba, Masanori,Hashiguchi, Shohei
, p. 63 - 73 (2007/10/03)
A novel lead compound, N-{3-[4-(4-fluorobenzoyl)piperidin-1-yl]propyl}-1- methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide (1), was identified as a CCR5 antagonist by high-throughput screening using [125I]RANTES and CCR5-expressing CHO cells. The IC50 value of 1 was 1.9 μM. In an effort to improve the binding affinity of 1, a series of 5-oxopyrrolidine-3- carboxamides was synthesized. Introduction of 3,4-dichloro substituents to the central phenyl ring (10i, IC50=0.057 μM; 11b, IC 50=0.050 μM) or replacing the 1-methyl group of the 5-oxopyrrolidine moiety with a 1-benzyl group (12e, IC50=0.038 μM) was found to be effective for improving CCR5 affinity. Compound 10i, 11b, and 12e also inhibited CCR5-using HIV-1 envelope-mediated membrane fusion with IC50 values of 0.44, 0.19, and 0.49 μM, respectively.
