129151-84-4Relevant articles and documents
Synthesis of the α-Methyl Ketoside of 5-Amino Neuraminic Acid Methyl Ester and Its Corresponding 5-Myristoyl and 5-Cyclopropanoyl Derivative
Schrell, Andreas,Whitesides, George M.
, p. 1111 - 1114 (2007/10/02)
This communication describes the first synthesis of the α-methyl ketoside of an N-unprotected neuraminic acid in the form of its methyl ester (Neu5NH21Me-α-2Me) (5a).This compound is a valuable intermediate for the synthesis of unnatural N-substituted sialic acids.Syntheses of Neu5myristoyl1Me-α-2Me (5b) and Neu5cyclopropanoyl1Me-α-2-Me (5c) are presented.