1291529-66-2

Upstream product

• 617-89-0 furan-2-ylmethanamine 
• 329-59-9 4-fluoro-3-nitro-benzoic acid methyl ester 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 954232-10-1 methyl 4-((furan-2-ylmethyl)amino)-3-nitrobenzoate 

Downstream Products

• 1383812-21-2 methyl 2-(2-chloro-3-nitrophenyl)-1-(furan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylate 
• 1383812-36-9 methyl 2-[6-(2-fluorophenyl)-1,2,6,7-tetrahydroindolo[1,7-ab][1,5]-benzodiazepin-11-yl]-1-(furan-2-ylmethyl)-1H-benzimidazole-5-carboxylate 
• 1383812-39-2 methyl 2-[6-(2-bromophenyl)-1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepin-11-yl]-1-(furan-2-ylmethyl)-1H-benzimidazole-5-carboxylate 
• 1383812-42-7 methyl 2-[6-(4-methoxyphenyl)-1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepin-11-yl]-1-(furan-2-ylmethyl)-1H-benzimidazole-5-carboxylate 
• 1383812-18-7 methyl 3-(2-chloro-3-nitrobenzamido)-4-((furan-2-ylmethyl)amino)benzoate 
• 1430101-71-5 methyl 2-(2-(benzo[d][1,3]dioxol-5-yl)-3-(benzylamino)imidazo[1,2-a]pyridin-6-yl)-1-(furan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylate 
• 1430101-70-4 methyl 2-(3-(cyclohexylamino)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-6-yl)-1-(furan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylate 
• 1430101-69-1 methyl 2-(3-(cyclohexylamino)-2-p-tolylimidazo[1,2-a]pyridin-6-yl)-1-(furan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylate 
• 1430101-68-0 methyl 2-(3-(benzylamino)-2-cyclohexylimidazo[1,2-a]pyridin-6-yl)-1-(furan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylate 
• 1430101-67-9 methyl 2-(3-(benzylamino)-2-p-tolylimidazo[1,2-a]pyridin-6-yl)-1-(furan-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylate 

Relevant academic research and scientific papers

NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS

The present invention provides novel substituted benzimidazole derivatives used as DAAO inhibitors and for treatment and/or prevention of neurological disorders.

Diversity-Oriented Synthesis of Coumarin-Linked Benzimidazoles via a One-Pot, Three-Step, Intramolecular Knoevenagel Cyclization

Diversity-oriented synthesis of coumarin-linked benzimidazoles from N-(2-aminophenyl)-2-cyanoacetamide was achieved via a one-pot, three-step sequential reaction in excellent yields. In situ intramolecular cyclization of the cyanoacetamide afforded benzimidazoles which subsequently underwent a Knoevenagel condensation of the 2-cyanomethylbenzimidazoles with salicylaldehydes promoted by triethylamine to reach the target compounds. An important intermediate, 2-(2-imino-2H-chromen-3-yl)-1H-benzimidazole was characterized by X-ray analysis and further hydrolyzed to 2-(coumarin-3-yl)benzimidazole in acidic condition. Among the synthesized compounds, some were found to be promising inhibitors of porcine kidney d-amino acid oxidase (pkDAO).

Synthesis of Aminofuran-Linked Benzimidazoles and Cyanopyrrole-Fused Benzimidazoles by Condition-Based Skeletal Divergence

A condition-based skeletal divergent synthesis was explored to achieve skeletal diversity in two component condensation reaction. Cyanomethyl benzimidazole was reacted with α-bromoketone under thermal conditions to furnish 2-aminofuranyl-benzimidazoles, w

Copper catalyzed aerobic oxidative cyclization and ketonization: One pot synthesis of benzoimidazo[1,2-: A] imidazolones

A highly efficient synthesis of benzoimidazo[1,2-a]imidazolone through a novel oxidative 5-exo-dig cyclization-ketonization cascade of 2-aminobenzimidazole, aldehyde and terminal alkyne has been explored under aerobic conditions. The reaction proceeds thr

Three Component Divergent Reactions: Base-Controlled Amphiphilic Synthesis of Benzimidazole-Linked Thiazetidines and Fused Thiadiazines

A divergent reaction of 2-aminobenzimidazole with isothiocyanates and dihalomethanes has been developed for the selective synthesis of benzoimidazothiazetidine and benzoimidazothiadiazine. A single-pot reaction of 2-aminobenzimidazole in the presence of s

Multicomponent solvent-free synthesis of benzimidazolyl imidazo[1,2-a]-pyridine under microwave irradiation

A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodology

Design and synthesis of new biprivileged molecular scaffolds: Indolo-fused benzodiazepinyl/quinoxalinyl benzimidazoles

The present article describes the design and synthesis of new biprivileged molecular scaffolds with diverse structural features. Commercially available, simple heterocyclic building blocks such as 4-fluoro-3-nitrobenzoic acid, 2-chloro-3-nitrobenzoic acid