129156-29-2Relevant academic research and scientific papers
Base-Promoted/Gold-Catalyzed Intramolecular Highly Selective and Controllable Detosylative Cyclization
Zhu, Chenghao,Qiu, Lin,Xu, Guangyang,Li, Jian,Sun, Jiangtao
supporting information, p. 12871 - 12875 (2015/09/07)
A highly selective, controllable and synthetically useful base-promoted intramolecular detosylative cyclization of bis-N-tosylhydrazones has been achieved, affording N-containing heterocycles and cyclic olefins under transition-metal-free or gold-catalyzed procedures, respectively. Moreover, an effective and practical metal-free or gold-catalyzed approach to synthesize polycyclic aromatic compounds is also reported. Basic cyclizations: A highly selective, controllable, and synthetically useful base-promoted intramolecular detosylative cyclization of bis-N-tosylhydrazones affords N-containing heterocycles and cyclic olefins under transition-metal-free or gold-catalyzed procedures, respectively. Moreover, an effective and practical metal-free or gold-catalyzed approach to synthesize polycyclic aromatic compounds is also reported.
New Low-Valent Titanium Reagents for Dicarbonyl Coupling and Their Use in a General Method of Annulation
Clive, Derrick L. J.,Zhang, Chengzhi,Murthy, K. S. Keshava,Hayward, William D.,Daigneault, Sylvain
, p. 6447 - 6458 (2007/10/02)
New low-valent titanium reagents have been prepared by reducing TiCl3 (1 mol) with C8K (2 mol) or by reducing TiCl4 (1 mol) with Na-naphthalene (2.75 mol).Ketones carrying a chain that incorporates a suitably placed oxo function (aldehyde or ketone) undergo intramolecular dicarbonyl coupling to produce a bicyclic compound when treated with an excess (16-17 mol of titanium halide per mol of dicarbonyl compound) of one of these reagents.The procedure works well even for highly oxygenated substrates and constitutes a general method of annulation.Other reducing agents besides C8K or Na-naphthalene are suitable, and a brief examination of Na(Hg) and Na-K alloy was made.The C8K/TiCl3 system was also used to convert a cis-1,2-diol into the corresponding olefin.
New Low-valent Titanium Reagents for Dicarbonyl Coupling and their Use in a General Method of Annulation
Clive, Derrick L. J.,Murthy, K. S. Keshava,Zhang, Chengzhi,Hayward, William D.,Daigneault, Sylvain
, p. 509 - 511 (2007/10/02)
Ketones carrying a chain that incorporates a suitably placed oxo function (aldehyde or ketone) undergo intramolecular dicarbonyl coupling when treated with a reagent prepared either from titanium trichloride and C8K (relative molar ratio 1:2) or from tita
